Echoes of Change: How Ultrasound Has Transformed Giant Cell Arteritis Detection

Authors

  • Maria Powell, MD, MSc (Med Ed), CIP, FRCPC Department of Medicine, University of Calgary, Calgary, Alberta Division of Rheumatology, University of Calgary, Calgary, Alberta
  • Mohammad Bardi, MD, FRCPC Department of Medicine, University of British Columbia, Vancouver, British Columbia Division of Rheumatology, Vancouver General Hospital, British Columbia Division of Rheumatology, St. Paul’s Hospital, Vancouver, British Columbia Giant Cell Arteritis Fast Track Clinic Lead, Vancouver, British Columbia

DOI:

https://doi.org/10.58931/crt.2024.1353

Abstract

Giant cell arteritis (GCA) is the most common form of vasculitis affecting adults. The diagnosis of GCA is suspected in patients older than 50 years of age with a new headache and elevated inflammatory markers. Once the diagnosis of GCA is suspected, patients require urgent treatment with glucocorticoids to prevent ischemic complications such as blindness and stroke. As there are many causes for headache, diagnosing GCA can be a ‘headache’ for many rheumatologists. For years, rheumatologists have relied on the temporal artery biopsy (TAB) as the gold standard for diagnosing GCA, despite the 33–92% sensitivity. As patients with suspected GCA remain on high doses of glucocorticoids, which have multiple side-effects and potential adverse events, rapid access to tests that have a greater impact on clinical decision‑making is essential. Vascular imaging is a non‑invasive tool that can help diagnose, monitor, and predict the course of GCA. This article will focus on how ultrasound has transformed the detection of GCA and its potential to reduce some of the ‘headaches’ faced by both rheumatologists and patients.

Author Biographies

Maria Powell, MD, MSc (Med Ed), CIP, FRCPC, Department of Medicine, University of Calgary, Calgary, Alberta Division of Rheumatology, University of Calgary, Calgary, Alberta

 

Dr. Powell is a Clinical Assistant Professor at the University of Calgary and a locum rheumatologist in Calgary, Alberta. Her clinical and research interests are on the use of musculoskeletal ultrasound (MSUS) in rheumatology. She holds a master’s degree in medical education with a focus on MSUS education in rheumatology. She has completed training in MSUS through the Canadian Rheumatology Ultrasound Society (CRUS) and is currently enrolled in the Ultrasound Society of North American Rheumatologists (USSONAR) fellowship program. She received the emerging investigator excellence award from the American College of Rheumatology (ACR) in 2023 to recognize her work on MSUS education in Canadian rheumatology residency programs.

Mohammad Bardi, MD, FRCPC, Department of Medicine, University of British Columbia, Vancouver, British Columbia Division of Rheumatology, Vancouver General Hospital, British Columbia Division of Rheumatology, St. Paul’s Hospital, Vancouver, British Columbia Giant Cell Arteritis Fast Track Clinic Lead, Vancouver, British Columbia

Dr. Bardi is a rheumatologist in Vancouver, British Columbia and a clinical instructor at the University of British Columbia (UBC). His focus in Rheumatology is on the use of ultrasound for the assessment of inflammatory arthritis and giant cell arteritis (GCA). He completed the Ultrasound Society of North American Rheumatologists (USSONAR) program and further international training in Norway and the United Kingdom. He is actively involved with the Canadian Rheumatology Ultrasound Society (CRUS) and USSONAR. He has established a GCA fast track clinic in Vancouver as well as a one-year fellowship in musculoskeletal ultrasound and GCA ultrasound training through UBC.

References

S, Mahr A. Sensitivity of temporal artery biopsy in the diagnosis of giant cell arteritis: a systematic literature review and meta-analysis. Rheumatology (Oxford). 2020;59(5):1011-1020. doi:10.1093/rheumatology/kez385

Rice JB, White AG, Scarpati LM, Wan G, Nelson WW. Long-term systemic corticosteroid exposure: a systematic literature review. Clin Ther. 2017;39(11):2216-2229. doi:10.1016/j.clinthera.2017.09.011

Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1-11. doi:10.1002/art.37715

Barra L, Pope JE, Pequeno P, Saxena FE, Bell M, Haaland D, et al. Incidence and prevalence of giant cell arteritis in Ontario, Canada. Rheumatology (Oxford). 2020;59(11):3250-3258. doi:10.1093/rheumatology/keaa095

Pugh D, Karabayas M, Basu N, Cid MC, Goel R, Goodyear CS, et al. Large-vessel vasculitis. Nat Rev Dis Primers. 2022;7(1):93. doi:10.1038/s41572-021-00327-5

Tomelleri A, van der Geest KSM, Khurshid MA, Sebastian A, Coath F, Robbins D, et al. Disease stratification in GCA and PMR: state of the art and future perspectives. Nat Rev Rheumatol. 2023;19(7):446-459. doi:10.1038/s41584-023-00976-8

Buttgereit F, Dejaco C, Matteson EL, Dasgupta B. Polymyalgia rheumatica and giant cell arteritis: a systematic review. JAMA. 2016;315(22):2442-2458. doi:10.1001/jama.2016.5444

Schmidt WA, Kraft HE, Vorpahl K, Völker L, Gromnica-Ihle EJ. Color duplex ultrasonography in the diagnosis of temporal arteritis. N Engl J Med. 1997;337(19):1336-1342. doi:10.1056/nejm199711063371902

Germanò G, Muratore F, Cimino L, Lo Gullo A, Possemato N, Macchioni P, et al. Is colour duplex sonography-guided temporal artery biopsy useful in the diagnosis of giant cell arteritis? A randomized study. Rheumatology (Oxford). 2015;54(3):400-404. doi:10.1093/rheumatology/keu241

Smetana GW, Shmerling RH. Does this patient have temporal arteritis? JAMA. 2002;287(1):92-101. doi:10.1001/jama.287.1.92

Gribbons KB, Ponte C, Craven A, Robson JC, Suppiah R, Luqmani R, et al. Diagnostic assessment strategies and disease subsets in giant cell arteritis: data from an international observational cohort. Arthritis Rheumatol. 2020;72(4):667-676. doi:10.1002/art.41165

Hunder GG, Bloch DA, Michel BA, Stevens MB, Arend WP, Calabrese LH, et al. The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum. 1990;33(8):1122-1128. doi:10.1002/art.1780330810

Pouncey AL, Yeldham G, Magan T, Lucenteforte E, Jaffer U, Virgili G. Halo sign on temporal artery ultrasound versus temporal artery biopsy for giant cell arteritis. Cochrane Database Syst Rev. 2024;2(2):Cd013199. doi:10.1002/14651858.CD013199.pub2

Schmidt WA. Ultrasound in the diagnosis and management of giant cell arteritis. Rheumatology (Oxford). 2018;57(suppl_2):ii22-ii31. doi:10.1093/rheumatology/kex461

Bosch P, Bond M, Dejaco C, Ponte C, Mackie SL, Falzon L, et al. Imaging in diagnosis, monitoring and outcome prediction of large vessel vasculitis: a systematic literature review and meta-analysis informing the 2023 update of the EULAR recommendations. RMD Open. 2023;9(3). doi:10.1136/rmdopen-2023-003379

Dejaco C, Ramiro S, Bond M, Bosch P, Ponte C, Mackie SL, et al. EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice: 2023 update. Ann Rheum Dis. 2024;83(6):741-751. doi:10.1136/ard-2023-224543

Bruyn GA, Iagnocco A, Naredo E, Balint PV, Gutierrez M, Hammer HB, et al. OMERACT definitions for ultrasonographic pathologies and elementary lesions of rheumatic disorders 15 years on. J Rheumatol. 2019;46(10):1388-1393. doi:10.3899/jrheum.181095

Aschwanden M, Daikeler T, Kesten F, Baldi T, Benz D, Tyndall A, et al. Temporal artery compression sign--a novel ultrasound finding for the diagnosis of giant cell arteritis. Ultraschall Med. 2013;34(1):47-50. doi:10.1055/s-0032-1312821

Schäfer VS, Juche A, Ramiro S, Krause A, Schmidt WA. Ultrasound cut-off values for intima-media thickness of temporal, facial and axillary arteries in giant cell arteritis. Rheumatology (Oxford). 2017;56(9):1479-1483. doi:10.1093/rheumatology/kex143

Dasgupta B, Smith K, Khan AAS, Coath F, Wakefield RJ. ‘Slope sign’: a feature of large vessel vasculitis? Ann Rheum Dis. 2019;78(12):1738. doi:10.1136/annrheumdis-2019-216213

Ponte C, Grayson PC, Robson JC, Suppiah R, Gribbons KB, Judge A, et al. 2022 American College of Rheumatology/EULAR classification criteria for giant cell arteritis. Ann Rheum Dis. 2022;81(12):1647-1653. doi:10.1136/ard-2022-223480

Luqmani R, Lee E, Singh S, Gillett M, Schmidt WA, Bradburn M, et al. The Role of ultrasound compared to biopsy of Temporal Arteries in the Diagnosis and Treatment of Giant Cell Arteritis (TABUL): a diagnostic accuracy and cost-effectiveness study. Health Technol Assess. 2016;20(90):1-238. doi:10.3310/hta20900

Patil P, Williams M, Maw WW, Achilleos K, Elsideeg S, Dejaco C, et al. Fast track pathway reduces sight loss in giant cell arteritis: results of a longitudinal observational cohort study. Clin Exp Rheumatol. 2015;33(2 Suppl 89):S-103-106.

Diamantopoulos AP, Haugeberg G, Lindland A, Myklebust G. The fast-track ultrasound clinic for early diagnosis of giant cell arteritis significantly reduces permanent visual impairment: towards a more effective strategy to improve clinical outcome in giant cell arteritis? Rheumatology (Oxford). 2016;55(1):66-70. doi:10.1093/rheumatology/kev289

Kermani TA, Warrington KJ, Cuthbertson D, Carette S, Hoffman GS, Khalidi NA, et al. Disease relapses among patients with giant cell arteritis: a prospective, longitudinal cohort study. J Rheumatol. 2015;42(7):1213-1217. doi:10.3899/jrheum.141347

Stone JH, Tuckwell K, Dimonaco S, Klearman M, Aringer M, Blockmans D, et al. Glucocorticoid dosages and acute-phase reactant levels at giant cell arteritis flare in a randomized trial of tocilizumab. Arthritis Rheumatol. 2019;71(8):1329-1338. doi:10.1002/art.40876

Kirby C, Flood R, Mullan R, Murphy G, Kane D. Evolution of ultrasound in giant cell arteritis. Front Med (Lausanne). 2022;9:981659. doi:10.3389/fmed.2022.981659

Ponte C, Monti S, Scirè CA, Delvino P, Khmelinskii N, Milanesi A, et al. Ultrasound halo sign as a potential monitoring tool for patients with giant cell arteritis: a prospective analysis. Ann Rheum Dis. 2021;80(11):1475-1482. doi:10.1136/annrheumdis-2021-220306

Maz M, Chung SA, Abril A, Langford CA, Gorelik M, Guyatt G, et al. 2021 American College of Rheumatology/Vasculitis Foundation Guideline for the management of giant cell arteritis and Takayasu arteritis. Arthritis Rheumatol. 2021;73(8):1349-1365. doi:10.1002/art.41774

van der Geest KSM, Wolfe K, Borg F, Sebastian A, Kayani A, Tomelleri A, et al. Ultrasonographic halo score in giant cell arteritis: association with intimal hyperplasia and ischaemic sight loss. Rheumatology (Oxford). 2021;60(9):4361-4366. doi:10.1093/rheumatology/keaa806

Soriano A, Muratore F, Pipitone N, Boiardi L, Cimino L, Salvarani C. Visual loss and other cranial ischaemic complications in giant cell arteritis. Nat Rev Rheumatol. 2017;13(8):476-484. doi:10.1038/nrrheum.2017.98

Dejaco C, Ponte C, Monti S, Rozza D, Scirè CA, Terslev L, et al. The provisional OMERACT ultrasonography score for giant cell arteritis. Ann Rheum Dis. 2023;82(4):556-64.

Molina-Collada J, Monjo-Henry I, Fernández-Fernández E, Álvaro-Gracia JM, de Miguel E. The OMERACT Giant cell arteritis Ultrasonography Score: a potential predictive outcome to assess the risk of relapse during follow-up. Rheumatology (Oxford). 2024.

Royal College of Physicians and Surgeons of Canada. Rheumatology Training Experiences. Ottawa; 2019. Available from: https://www.royalcollege.ca/content/dam/documents/ibd/rheumatology/rheumatology-rte-training-experiences-e.pdf.

Ludwig DR, Vöö S, Morris V. Fast-track pathway for early diagnosis and management of giant cell arteritis: the combined role of vascular ultrasonography and [18F]-fluorodeoxyglucose PET-computed tomography imaging. Nucl Med Commun. 2023;44(5):339-344. doi:10.1097/mnm.0000000000001670

Fernández-Fernández E, Monjo-Henry I, Bonilla G, Plasencia C, Miranda-Carús ME, Balsa A, et al. False positives in the ultrasound diagnosis of giant cell arteritis: some diseases can also show the halo sign. Rheumatology (Oxford). 2020;59(9):2443-2447. doi:10.1093/rheumatology/kez641

Schmidt WA, Czihal M, Gernert M, Hartung W, Hellmich B, Ohrndorf S, et al. Recommendations for defining giant cell arteritis fast-track clinics. English version. Z Rheumatol. 2024. doi:10.1007/s00393-024-01532-9

Downloads

Published

2024-12-18

How to Cite

1.
Powell M, Bardi M. Echoes of Change: How Ultrasound Has Transformed Giant Cell Arteritis Detection. Can Rheumatol Today [Internet]. 2024 Dec. 18 [cited 2024 Dec. 21];1(3):4–11. Available from: https://canadianrheumatologytoday.com/article/view/1-3-Powell_et_al

Issue

Section

Articles